Sometimes, in very early kidney dysfunction (especially when the kidneys are damaged by diabetes), measured or estimated creatinine clearance may actually be high, indicating that the kidneys are working harder than normal.ĬKD stages according to eGFR and albumin to creatinine ratio (ACR) (Source) NICE guidelines (CG182) Creatinine Clearance results are usually evaluated in the same way. A normal result means that kidney disease is less likely while a low value suggests that some kidney dysfunction is present. The calculation of eGFR which has been adopted in the UK uses a formula which uses the concentration of creatinine in blood, the age and sex of the patient and their ethnic origin.ĮGFR or Calculated Creatinine Clearance is a simple test to detect early changes in kidney function. eGFR or calculated creatinine clearance are based on serum creatinine, an easily performed and commonly used laboratory test. In the UK, NICE Guidance (CG182) states: “Whenever a request for serum creatinine measurement is made, clinical laboratories should report an estimate of GFR (eGFR)”.Ĭreatinine Clearance is a more accurate way to detect changes in kidney status than measurement of serum urea and creatinine alone, which are easier to do but cannot pick up early damage to the kidneys. This is now routinely performed every time a serum creatinine concentration is requested to evaluate the status of the kidneys in those with, or at risk of, kidney damage such as individuals with diabetes or hypertension, where early intervention can prevent further damage. The eGFR is used to screen for and detect early kidney damage and to monitor kidney function. Using the creatinine test result, a reasonable estimate of the actual GFR can be determined. When kidney function decreases, less creatinine is excreted and concentrations increase in the blood. Creatinine is a muscle waste product that is filtered from the blood by the kidneys and excreted into the urine at a relatively steady rate. The eGFR is a calculation based on a serum creatinine test result mainly, but serum cystatin C may substitute creatinine or be included with creatinine. Because of this, an estimate – the eGFR – is usually used. This is important, as symptoms of kidney disease may not be noticeable until as much as 30 to 40% of kidney function is lost.Ī measured GFR is considered the most accurate way to detect changes in kidney status, but measuring the GFR directly is complicated, requires experienced personnel, and is typically performed in a research setting. Early detection of kidney dysfunction can help to minimise the damage. CKD can be seen with a variety of conditions, including diabetes and high blood pressure. When a person's kidney function declines due to damage or disease, the filtration rate decreases and waste products begin to accumulate in the blood.Ĭhronic kidney disease (CKD) is associated with a decrease in kidney function that is often progressive. The rate refers to the amount of blood that is filtered per minute. Glomeruli are tiny filters in your kidney that allow waste products to be removed from the blood, while preventing loss of important proteins and blood cells. Glomerular filtration rate (GFR) is a measure of the function of your kidneys. We are not a laboratory and are unable to comment on an individual's health and treatment. Lab Tests Online-UK is an educational website designed to provide patients and carers with information on laboratory tests used in medical care. If you are concerned about your test results, you will need to arrange an appointment with your doctor so that all relevant information including age, ethnicity, health history, signs and symptoms, laboratory and other procedures (radiology, endoscopy, etc.), can be considered. If the doctor wants to see you about the result(s), you will be offered an appointment. Your GP practice will be able to provide specific details. If you are registered to use the online services of your local practice, you may be able to access your results online. The X-ray & scan results may take longer. Some specialist test results may take longer, if samples have to be sent to a reference (specialist) laboratory. On average it takes 7 working days for the blood test results to come back from the hospital, depending on the exact tests requested. Urine Protein and Urine Protein to Creatinine Ratio.Urine Albumin to Creatinine Ratio or ACR.Unvalidated or misleading laboratory tests.Red Blood Cell (RBC) Antibody Identification.Heparin-induced Thrombocytopenia Antibody.Genetic Tests for Targeted Cancer Therapy.First Trimester (Combined) Screen for Down’s Syndrome and other fetal anomalies.Factor V Leiden Mutation and PT 20210 Mutation.
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